Transcriptomics

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Transcription profiling by array of human HepG2 cells treated with false positive genotoxins, true genotoxins and non-genotoxins


ABSTRACT: In this study we aimed to identify the molecular pathways modified by the false positive genotoxins Quercetin, 8-Hydroxyquinoline and 17beta-Estradiol that may explain their in vitro genotoxic and their in vivo non-genotoxic effects, by combining in vitro transcriptomics with phenotypic data. The effects of the false positive genotoxins were compared to the effects of the true genotoxins Benzo[a]pyrene and Aflatoxin B1 and the non-genotoxins 2,3,7,8-Tetrachlorodibenzodioxin, Cyclosporin A and Ampicillin C.

A custom CDF for use with the processed data file is available on the FTP site for this experiment.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Christina Magkoufopoulou   

PROVIDER: E-MEXP-2574 | ArrayExpress | 2011-01-01

REPOSITORIES: ArrayExpress

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