Transcriptomics

Dataset Information

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Transcription profiling by array of human HT29 colorectal cells treated with eicosapentaenoic acid


ABSTRACT: Effects of eicosapentaenoic acid on gene expression profiles in HT29 human colorectal cells

ORGANISM(S): Homo sapiens  

DISEASE(S): Colonic Adenocarcinoma

SUBMITTER: Ruan Elliott  

PROVIDER: E-MEXP-2673 | ArrayExpress | 2011-04-12

REPOSITORIES: ArrayExpress

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Publications

Identification of the Eph receptor pathway as a novel target for eicosapentaenoic acid (EPA) modification of gene expression in human colon adenocarcinoma cells (HT-29).

Doleman Joanne F JF   Eady John J JJ   Elliott Ruan M RM   Foxall Rob J RJ   Seers John J   Johnson Ian T IT   Lund Elizabeth K EK  

Nutrition & metabolism 20100712


BACKGROUND: The health benefits of polyunsaturated fatty acids (PUFAs), particularly those of the n-3 series are well documented. The mechanisms by which these effects are mediated are not fully clarified. METHODS: We used microarrays to assess the effects on gene expression in HT29 colon adenocarcinoma cells of exposure to the n-3 fatty acid eicosapentaenoic acid (EPA). HT29 cells were cultured with EPA (150 muM) for up to 24 hr prior to harvesting and isolation of RNA. Microarray results were  ...[more]

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