Transcriptomics

Dataset Information

47

Transcription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient


ABSTRACT: We compared gene expression profiles between asymptomatic and symptomatic atherosclerotic plaques from the same patient. This was accomplished by analyzing carotid plaques from four patients with bilateral high-grade carotid artery stenoses one being symptomatic (TIA or stroke) and the other asymptomatic.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Internal Carotid Artery Stenosis (nci Metathesaurus C0340569) Has Diseasestaging Asymptomatic,Internal Carotid Artery Stenosis (nci Metathesaurus C0340569) Has Diseasestaging Symptomatic

SUBMITTER: Petra Ijas  

PROVIDER: E-MEXP-268 | ArrayExpress | 2006-02-10

REPOSITORIES: ArrayExpress

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Publications

Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques.

Ijäs Petra P   Nuotio Krista K   Saksi Jani J   Soinne Lauri L   Saimanen Eija E   Karjalainen-Lindsberg Marja-Liisa ML   Salonen Oili O   Sarna Seppo S   Tuimala Jarno J   Kovanen Petri T PT   Kaste Markku M   Lindsberg Perttu J PJ  

Arteriosclerosis, thrombosis, and vascular biology 20061109 1


We studied by microarray analysis whether symptomatic and asymptomatic carotid plaques from the same patient differ in gene expression and whether the same changes are present in an independent sample set.Carotid plaques from four patients with bilateral high-grade stenosis, one being symptomatic and the other asymptomatic, were analyzed on Affymetrix U95Av2 arrays. 33 genes showed >1.5-fold change between symptomatic and asymptomatic plaques in an intraindividual comparison with FDR ranging fro  ...[more]

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