Transcriptomics

Dataset Information

45

Transcription profiling by array of human adrenocortical carcinoma cell line NCI-H295R treated with siRNA targeting SF-1 or RNF31 combined with forskolin treatment


ABSTRACT: The human adrenocortical carcinoma cell line NCI-H295R treated with siRNA targeting SF-1 or RNF31 with luciferase-targeting siRNA as control. Combined with forskolin treatment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Philip Jonsson  

PROVIDER: E-MEXP-3259 | ArrayExpress | 2012-02-01

REPOSITORIES: ArrayExpress

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Publications

Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFβ, and Wnt/β-catenin signaling in adrenocortical carcinoma cells.

Ehrlund Anna A   Jonsson Philip P   Vedin Lise-Lotte LL   Williams Cecilia C   Gustafsson Jan-Åke JÅ   Treuter Eckardt E  

PloS one 20120309 3


The orphan nuclear receptor Steroidogenic Factor-1 (SF-1, NR5A1) is a critical regulator of development and homeostasis of the adrenal cortex and gonads. We recently showed that a complex containing E3 ubiquitin ligase RNF31 and the known SF-1 corepressor DAX-1 (NR0B1) interacts with SF-1 on target promoters and represses transcription of steroidogenic acute regulatory protein (StAR) and aromatase (CYP19) genes. To further evaluate the role of SF-1 in the adrenal cortex and the involvement of RN  ...[more]

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