Dataset Information


Transcription profiling by array to study the response of Clostridium acetobutylicum to iron limitation and inactivation of ferric uptake regulator (fur)

ABSTRACT: Clostridium acetobutylicum is a Gram-positive, endospore-forming bacterium that is considered as a strict anaerobe. It ferments sugars to the organic acids acetate and butyrate or shifts to formation of the solvents - ethanol, butanol and acetone. In most bacteria the major regulator of iron homeostasis is Fur (ferric uptake regulator). Analysis of the genome of Clostridium acetobutylicum has revealed three genes encoding Fur-like proteins. The amino acid sequece of one of them showed 70% similarity to the Fur protein of the closely related Bacillus subtilis.
Thus, to gain insight into the role of Fur and the mechanisms for maintenance of iron homeostasis in this strict anaerobic organism, we determined its transcriptional profile in response to iron limitation and inactivation of fur.

ORGANISM(S): Clostridium acetobutylicum  

SUBMITTER: Delyana P Vasileva  

PROVIDER: E-MEXP-3401 | ArrayExpress | 2012-03-30


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