Transcriptomics

Dataset Information

40

Transcription profiling of 13.5dpc embryonic gonad/mesonephros from male Mrotm1H/Mrotm1H mice vs male wild type littermates


ABSTRACT: Direct comparison of gene expression in 13.5dpc embryonic gonad/mesonephros between male Mrotm1H/Mrotm1H mice and male wild-type littermates. Two independent pools of 10 gonads (5 mice) were compared on 4 microarrays (two colourswaps).

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Mus musculus  

SUBMITTER: Peter Underhill  

PROVIDER: E-MEXP-527 | ArrayExpress | 2007-01-09

REPOSITORIES: ArrayExpress

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Publications

The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice.

Smith Lee L   Willan John J   Warr Nick N   Brook Frances A FA   Cheeseman Michael M   Sharpe Richard R   Siggers Pam P   Greenfield Andy A  

PloS one 20081231 12


The mammalian gonad arises as a bipotential primordium from which a testis or ovary develops depending on the chromosomal sex of the individual. We have previously used DNA microarrays to screen for novel genes controlling the developmental fate of the indifferent embryonic mouse gonad. Maestro (Mro), which encodes a HEAT-repeat protein, was originally identified as a gene exhibiting sexually dimorphic expression during mouse gonad development. Wholemount in situ hybridisation analysis revealed  ...[more]

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