Transcriptomics

Dataset Information

4

Transcription profiling of long-lived C.elegans daf-2 pathway mutants with wild type/short-lived mutants


ABSTRACT: Comparison of long-lived daf-2 pathway mutants with wild type/short-lived mutants. A: age-1 fer-15; fem-1 vs. fer-15; fem-1. B: age-1 fer-15; fem-1 vs. fer-15; fem-1. C: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. D: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. E: daf-16::gfp in daf-16(mu86);daf-2(e1370) vs. daf-16(mu86);daf-2(e1370). F: daf-2(e1368); fer-15; fem-1 vs. fer-15; fem-1. G: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. H: age-1 fer-15; fem-1 vs. fer-15; fem-1. I: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. J: daf-16::gfp in daf-2(e1370); daf-16(mu86) vs. daf-2(e1370); daf-16(mu86). K: daf-2(mu150) vs. wild type. L: daf-2(e1370) vs. daf-2(e1370); daf-16(mu86). M: daf-2(e1370) vs. daf-2(e1370); daf-16(mu86). N: daf-2(e1370) vs. daf-2(e1370); daf-16(mu86).

INSTRUMENT(S): (Make:Axon Instruments,Model:GenePix 4000A)

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Andrew Fraser   Hao Li  Cynthia J Kenyon  Ravi S Kamath  Steven A McCarroll  Coleen T Murphy  Cornelia I Bargmann  Julie Ahringer 

PROVIDER: E-MEXP-7 | ArrayExpress | 2003-07-17

REPOSITORIES: ArrayExpress

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Publications

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.

Murphy Coleen T CT   McCarroll Steven A SA   Bargmann Cornelia I CI   Fraser Andrew A   Kamath Ravi S RS   Ahringer Julie J   Li Hao H   Kenyon Cynthia C  

Nature 20030629 6946


Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin-like growth factor 1 (IGF-I) signalling. Using DNA microarray analysis, we have found that DAF-16 affects expression of a set of genes during early adulthood, the time at which this pathway is known to control ageing. Here we find that many of these genes influence the ageing process. The insulin/IGF-I pathway fun  ...[more]

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