Ontology highlight
ABSTRACT:
INSTRUMENT(S): (Make:Axon Instruments,Model:GenePix 4000A)
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Andrew Fraser Hao Li Cynthia J Kenyon Ravi S Kamath Steven A McCarroll Coleen T Murphy Cornelia I Bargmann Julie Ahringer
PROVIDER: E-MEXP-7 | ArrayExpress | 2003-07-17
REPOSITORIES: ArrayExpress
Nature 20030629 6946
Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin-like growth factor 1 (IGF-I) signalling. Using DNA microarray analysis, we have found that DAF-16 affects expression of a set of genes during early adulthood, the time at which this pathway is known to control ageing. Here we find that many of these genes influence the ageing process. The insulin/IGF-I pathway fun ...[more]