Transcriptomics

Dataset Information

8

Comparative genomic hybridization of human leiomyosarcomas and gastrointestinal stromal tumors


ABSTRACT: Profiling of DNA copy number changes in human Leiomyosarcomas and Gastrointestinal Stromal Tumors using array CGH

INSTRUMENT(S): Agilent G2565BA

ORGANISM(S): Homo sapiens  

DISEASE(S): Leiomyosarcoma,Gastrointestinal Stromal Tumor,Normal

SUBMITTER: Junbai Wang   Ana H Barragan-Polania  Bodil Bjerkehagen  Hege O Ohnstad  Heidi M Namløs  Ola Myklebost  Bjørn E Kristiansen  Leonardo A Meza-Zepeda  Stine H Kresse 

PROVIDER: E-MEXP-707 | ArrayExpress | 2006-09-20

REPOSITORIES: ArrayExpress

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Publications

Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas.

Meza-Zepeda Leonardo A LA   Kresse Stine H SH   Barragan-Polania Ana H AH   Bjerkehagen Bodil B   Ohnstad Hege O HO   Namløs Heidi M HM   Wang Junbai J   Kristiansen Bjørn E BE   Myklebost Ola O  

Cancer research 20060901 18


Leiomyosarcomas are spindle cell tumors showing smooth muscle differentiation. Until recently, most gastrointestinal stromal tumors (GIST) were also classified as smooth muscle tumors, but now GISTs are recognized as a separate entity, defined as spindle cell and/or epithelioid tumors localized in the gastrointestinal tract. Using microarray-based comparative genomic hybridization (array CGH), we have created a detailed map of DNA copy number changes for 7 GISTs and 12 leiomyosarcomas. Considera  ...[more]

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