Transcriptomics

Dataset Information

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RNA-seq of human colon biopsy tissue of healthy segments, from advanced breast cancer patients treated with capecitabine (5-FU)


ABSTRACT: ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitro-in vivo translation in toxicological studies, as well as translation between non-clinical species (such as rat and mouse) and humans. This experimental setup therefore aimed to investigate the effects of capecitabine, which is activated into 5-FU in the body, on advanced breast cancer patients. Healthy colon tissue was collected from the patients before and after the first cycle of the monotherapy, which consists of 2 weeks treatment followed by 1 week rest. Each patient was their own control sample. Transcriptomic data collected from the colon biopsies was compared with previous data collected from colon organoids to verify for the translatability of the in vitro model to humans. This dataset is part of the TransQST collaboration.

INSTRUMENT(S): Illumina NovaSeq 6000

DISEASE(S): Control,Triple-negative Breast Cancer

SUBMITTER: Daniela Ferreira Garcia Rodrigues   Theo de Kok  

PROVIDER: E-MTAB-11295 | ArrayExpress | 2022-08-01

SECONDARY ACCESSION(S): ERP134493

REPOSITORIES: ArrayExpress, ENA

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