Transcriptomics

Dataset Information

238

Transcriptional profiling of miRNA in CD4+ T-cells from brain of EAE+Vehicle and EAE+DIM mice


ABSTRACT: C57BL/6 mice were immunized by subcutaneous injection of MOG35-55 peptide.DIM post-treatment was given at DAY 10 of the disease progression. CD4 T cells were isolated from the brain of the mice on day 15 of the MOG35-55 peptide immunization. Total RNA was extracted and subjected to microRNA high-throughput array with Affymetrix platform.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Roshni Rao  

PROVIDER: E-MTAB-2026 | ArrayExpress | 2013-11-01

REPOSITORIES: ArrayExpress

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Publications

Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells.

Rouse Michael M   Singh Narendra P NP   Nagarkatti Prakash S PS   Nagarkatti Mitzi M  

British journal of pharmacology 20130701 6


Dietary indole derivatives, indole-3-carbinol (I3C) and diindolylmethane (DIM), possess anti-cancer properties and exhibit the characteristics of aryl hydrocarbon receptor (AhR) ligands. Because AhR activation has recently been shown to regulate T cell differentiation, we tested the hypothesis that I3C and DIM may mediate anti-inflammatory properties by promoting regulatory T cell (T-regs) differentiation while inhibiting Th17 cells.We investigated the therapeutic efficacy of I3C and DIM against  ...[more]

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