Transcriptomics

Dataset Information

124

A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.


ABSTRACT: Wildtype and set2delta strains, with samples taken at t=0 and following 30 minutes treatment with 5 µg/ml bleomycin.

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Timothy C Humphrey   Simon Whitehall   Carol Walker   Sovan Sarkar   Lydia Hulme   Jürg Bähler   Sandra Codlin   Chen-Chun Pai  Csenge Gal  Elizabeth J Blaikley  Eric Bernhard  Lakxmi Subramanian  Robin Allshire  Rachel S Deegan 

PROVIDER: E-MTAB-2549 | ArrayExpress | 2014-06-09

REPOSITORIES: ArrayExpress

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Publications


DNA double-strand break (DSB) repair is a highly regulated process performed predominantly by non-homologous end joining (NHEJ) or homologous recombination (HR) pathways. How these pathways are coordinated in the context of chromatin is unclear. Here we uncover a role for histone H3K36 modification in regulating DSB repair pathway choice in fission yeast. We find Set2-dependent H3K36 methylation reduces chromatin accessibility, reduces resection and promotes NHEJ, while antagonistic Gcn5-depende  ...[more]

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