Transcriptomics

Dataset Information

298

Identification of Wig-1-associated RNAs by RNA-immunoprecipitation followed by high-throughput sequencing in HCT116 and Saos2 cancer cell lines


ABSTRACT: Identification of Wig-1-associated RNAs by RNA-immunoprecipitation followed by high-throughput sequencing in HCT116 and Saos2 cancer cell lines

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

SUBMITTER: Klas Wiman   Cinzia Bersani   Mikael Huss 

PROVIDER: E-MTAB-2840 | ArrayExpress | 2015-12-31

SECONDARY ACCESSION(S): ERP006686

REPOSITORIES: ArrayExpress, ENA

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Publications


RNA-binding proteins (RBPs) play important roles in the regulation of gene expression through a variety of post-transcriptional mechanisms. The p53-induced RBP Wig-1 (Zmat3) binds RNA through its zinc finger domains and enhances stability of p53 and N-Myc mRNAs and decreases stability of FAS mRNA. To identify novel Wig-1-bound RNAs, we performed RNA-immunoprecipitation followed by high-throughput sequencing (RIP-Seq) in HCT116 and Saos-2 cells. We identified 286 Wig-1-bound mRNAs common between  ...[more]

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