Genomics

Dataset Information

301

SP1/2/3 and NfY cooccurency in MEFs


ABSTRACT: Investigation of the binding behaviour of Sp1, Sp2, Sp3 and NF-ya, NF-yb and NF-yc in mouse embryonic fibroblasts and of Sp1, Sp2 and Sp3 in HEK-293 cells reveals distinct binding of the seemingly similar transcription factors Sp1/3 and Sp2.

INSTRUMENT(S): Illumina HiSeq 1000

ORGANISM(S): Musculus  

SUBMITTER: Florian Finkernagel   Guntram Suske   Bastian Stielow  

PROVIDER: E-MTAB-2970 | ArrayExpress | 2015-01-30

SECONDARY ACCESSION(S): ERP007114

REPOSITORIES: ArrayExpress, ENA

altmetric image

Publications

Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.

Völkel Sara S   Stielow Bastian B   Finkernagel Florian F   Stiewe Thorsten T   Nist Andrea A   Suske Guntram G  

PLoS genetics 20150320 3


Transcription factors are grouped into families based on sequence similarity within functional domains, particularly DNA-binding domains. The Specificity proteins Sp1, Sp2 and Sp3 are paradigmatic of closely related transcription factors. They share amino-terminal glutamine-rich regions and a conserved carboxy-terminal zinc finger domain that can bind to GC rich motifs in vitro. All three Sp proteins are ubiquitously expressed; yet they carry out unique functions in vivo raising the question of  ...[more]

Similar Datasets

| GSE56838 | GEO
2014-08-14 | E-GEOD-56838 | ArrayExpress
2014-08-14 | E-GEOD-56839 | ArrayExpress
2012-04-24 | E-GEOD-36092 | ArrayExpress
2012-02-13 | E-GEOD-30083 | ArrayExpress
2014-12-18 | E-GEOD-58707 | ArrayExpress
2012-12-31 | E-GEOD-40215 | ArrayExpress
2016-07-03 | E-GEOD-70543 | ArrayExpress
2012-05-24 | E-MTAB-994 | ArrayExpress
2011-08-24 | E-GEOD-31628 | ArrayExpress