Transcriptomics

Dataset Information

51

CD8+/CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients


ABSTRACT: We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T-cell distribution and functions, and the prognosis significance of TIL subpopulations in non-small cell lung carcinoma (NSCLC) have thus far not been systematically addressed. Here we investigate the transcriptomic profil of these cell population, using PBMC cells as control.

ORGANISM(S): Homo sapiens  

SUBMITTER: Guillaume Meurice   Fathia Mami-Chouaib  

PROVIDER: E-MTAB-3266 | ArrayExpress | 2015-06-29

REPOSITORIES: ArrayExpress

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Publications

CD8+CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients.

Djenidi Fayçal F   Adam Julien J   Goubar Aïcha A   Durgeau Aurélie A   Meurice Guillaume G   de Montpréville Vincent V   Validire Pierre P   Besse Benjamin B   Mami-Chouaib Fathia F  

Journal of immunology (Baltimore, Md. : 1950) 20150227 7


We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T cell distribution and functions and the prognosis significance of TIL subpopulations in non-small cell lung carcinoma (NSCLC) have thus far not been systematically addressed. In this study, we show that an enhanced CD103(+) TIL subset correlates with improved early s  ...[more]

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