Transcriptomics

Dataset Information

42

Genome-scale ChIP-on-chip study into the role of AbsA2 in regulating antibiotic biosynthesis in Streptomyces coelicolor


ABSTRACT: Here we report the construction of a absA2 mutant strain which exhibited the classic precocious hyper-production of antibiotics and its complementation by an N-terminal triple-FLAG tagged version of AbsA2. The complemented and non-complemented absA2 mutant strains were used in large-scale time-course experiments to investigate the effect of deleting absA2 on gene expression at multiple time points and identify AbsA2 DNA binding sites in ChIP-on-chip studies using high-density microarrays.

SUBMITTER: Colin P Smith   Emma Laing  

PROVIDER: E-MTAB-3527 | ArrayExpress | 2019-02-16

REPOSITORIES: ArrayExpress

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