Transcriptomics

Dataset Information

4

MicroRNA array of SH-SY5Y cells


ABSTRACT: This experiment captures expression over 60,000 well-annotated RefSeq human transcripts over RNA samples from SH-SY5Y neuroblastoma cells transfected with human and non-human primate microRNA mimic variants of miR-299-3p, miR-503-3p, miR-508-3p and miR-541-3p, as well as a RNA duplex negative control (C2 mimic, Dharmacon).

ORGANISM(S): Homo sapiens  

SUBMITTER: Yolanda Espinosa-Parrilla   Alicia Gallego  

PROVIDER: E-MTAB-3617 | ArrayExpress | 2016-04-03

REPOSITORIES: ArrayExpress

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Publications


microRNAs are crucial post-transcriptional regulators of gene expression involved in a wide range of biological processes. Although microRNAs are highly conserved among species, the functional implications of existing lineage-specific changes and their role in determining differences between humans and other great apes have not been specifically addressed. We analyzed the recent evolutionary history of 1,595 human microRNAs by looking at their intra- and inter-species variation in great apes usi  ...[more]

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