Dataset Information


Proteomic profiling of colorectal cancer cell culture samples treated with apoptosis- and mTOR inhibitors under normoxia and hypoxia

ABSTRACT: To examine changes in tyrosine kinase activity in colorectal cancer cell culture samples treated with apoptosis inhibitors or/and mTOR inhibitors, under normoxic or/and hypoxic experimental conditions.

ORGANISM(S): Homo sapiens  

SUBMITTER: Kathrine R Redalen  

PROVIDER: E-MTAB-3870 | ArrayExpress | 2016-06-15


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Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells.

Risberg Karianne K   Redalen Kathrine Røe KR   Sønstevold Linda L   Bjørnetrø Tonje T   Sølvernes Janne J   Ree Anne Hansen AH  

BMC cancer 20160726

BACKGROUND:The use of targeted agents to impel dual inhibition of anti-apoptotic mechanisms and mTOR-mediated pro-survival signaling in colorectal carcinoma (CRC) cell lines with KRAS or BRAF mutation has been shown to induce apoptosis, a timely result given CRC entities harboring such mutations are in need of new therapies. Since CRC comprises heterogeneous tumors with predominant hypoxic components, we investigated effects of an inhibitor of anti-apoptotic Bcl-2 family proteins (ABT-737) in co  ...[more]

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