Transcriptomics

Dataset Information

48

Transcription profiling by array of human H9 embryonic stem cells differentiated towards early endoderm over 72 hours in chemically defined media


ABSTRACT: Transcriptional profiling of H9 human embryonic stem cells differentiated towards early endoderm over 72 hours in chemically defined media.

ORGANISM(S): Homo sapiens  

SUBMITTER: Matthew Trotter   

PROVIDER: E-MTAB-467 | ArrayExpress | 2012-01-25

REPOSITORIES: ArrayExpress

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Publications

Pluripotency factors regulate definitive endoderm specification through eomesodermin.

Teo Adrian Kee Keong AK   Arnold Sebastian J SJ   Trotter Matthew W B MW   Brown Stephanie S   Ang Lay Teng LT   Chng Zhenzhi Z   Robertson Elizabeth J EJ   Dunn N Ray NR   Vallier Ludovic L  

Genes & development 20110118 3


Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective toward the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types. Here, we used human embryonic stem cells and mouse epiblast stem cells to study specification of definitive endoderm in vitro. Using a combination of whole-genome expression and chromatin immunoprecipitation (ChIP) deep sequencing (ChIP-seq) analyses, we es  ...[more]

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