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Whole transcriptomic analysis of mouse ATDC5 chondrocyte precursor cells under 25 MPa hydrostatic pressure for 0, 1 , 4 or 24h

ABSTRACT: Hydrostatic pressure is one of the main mechanical stimuli cartilage cells are submitted to during joint loading. If moderate hydrostatic pressure is known to be beneficial to cartilage differentiation, excessive pressure, on the other hand, induces changes in cartilage similar to those observed in osteoarthritic cartilage. Therefore, the purpose of the experiment is to identify new target genes of high hydrostatic pressure in chondrocyte precursor cells.

ORGANISM(S): Mus musculus  

SUBMITTER: Takashi Ushida   Kevin Montagne  

PROVIDER: E-MTAB-5326 | ArrayExpress | 2017-12-02


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High hydrostatic pressure induces pro-osteoarthritic changes in cartilage precursor cells: A transcriptome analysis.

Montagne Kevin K   Onuma Yasuko Y   Ito Yuzuru Y   Aiki Yasuhiko Y   Furukawa Katsuko S KS   Ushida Takashi T  

PloS one 20170816 8

Due to the high water content of cartilage, hydrostatic pressure is likely one of the main physical stimuli sensed by chondrocytes. Whereas, in the physiological range (0 to around 10 MPa), hydrostatic pressure exerts mostly pro-chondrogenic effects in chondrocyte models, excessive pressures have been reported to induce detrimental effects on cartilage, such as increased apoptosis and inflammation, and decreased cartilage marker expression. Though some genes modulated by high pressure have been  ...[more]

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