Genomics

Dataset Information

341

ChIP-seq of PDAC tissues grown as patient-derived tumor xenografts


ABSTRACT: Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies and a major health problem. Patient-derived tumor xenografts (PDTXs) have been increasingly used as a prime approach for preclinical studies despite being insufficiently characterized as a model of the human disease and its diversity. Extensive multiomics characterization of these PDTXs have demonstrated their utility as a suitable model for preclinical studies, representing the diversity of the primary cancers. We performed a multi-factorial integrative analysis of genome-wide ChIP-seq on multiple histone modifications, as well as RNA-seq on subcutaneous PDTXs from 24 PDAC samples obtained either surgically or using diagnostic biopsies (endoscopic ultrasound guided fine needle aspirate). In the dataset, ChIP-seq for five distinct histone marks (H3K4me1, H3K27ac, H3K4me3, H3K27me3, and H3K9me3) and RNA-seq was carried out to generate new knowledge on the epigenetic landscapes underlying the heterogeneity of PDAC tissues grown in this manner.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

SUBMITTER: Gwen A Lomberk,   Krutika Satish Gaonkar  

PROVIDER: E-MTAB-5632 | ArrayExpress | 2018-05-29

SECONDARY ACCESSION(S): ERP023823

REPOSITORIES: ArrayExpress, ENA

Similar Datasets

2017-12-12 | E-MTAB-5039 | ArrayExpress
2017-12-12 | E-MTAB-5006 | ArrayExpress
2017-12-12 | E-MTAB-5018 | ArrayExpress
2018-05-29 | E-MTAB-5639 | ArrayExpress
2017-12-12 | E-MTAB-5008 | ArrayExpress
| GSE63111 | GEO
| GSE56560 | GEO
2015-01-20 | E-GEOD-52812 | ArrayExpress
2014-07-08 | E-GEOD-49149 | ArrayExpress
2013-08-12 | E-GEOD-49641 | ArrayExpress