Transcriptomics

Dataset Information

0

RNA-seq of definitive endoderm and pancreatic progenitor cells derived in vitro from human pluripotent stem cells in order to study the role of transcription factor GATA6 in human pancreas development


ABSTRACT: Mutant GATA6 hPSCs were obtained by TALEN genome editing or re-programmed from patient fibroblasts. Along with wild-type H9 cells, these GATA6 mutant cell lines were differentiated into SOX17+/CXCR4+ endodermal cells (day 3) and PDX1+ pancreatic progenitor cells (day 12). The purpose of this work was to study the role of GATA6 in the development of the human pancreas at a molecular level.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens  

SUBMITTER: Ludovic Vallier   Crystal Chia   Ray Dunn  

PROVIDER: E-MTAB-5958 | ArrayExpress | 2019-03-13

SECONDARY ACCESSION(S): ERP024453

REPOSITORIES: ArrayExpress, ENA

Similar Datasets

2019-03-13 | E-MTAB-5959 | ArrayExpress
2016-07-28 | E-GEOD-81711 | ArrayExpress
2019-02-09 | E-MTAB-7008 | ArrayExpress
2018-07-26 | E-MTAB-6819 | ArrayExpress
2016-06-02 | E-GEOD-82103 | ArrayExpress
2018-10-05 | E-MTAB-6268 | ArrayExpress
2012-12-20 | E-GEOD-34304 | ArrayExpress
2011-07-18 | E-GEOD-30176 | ArrayExpress
2012-12-20 | E-GEOD-34279 | ArrayExpress
2015-06-30 | E-GEOD-69322 | ArrayExpress