Transcriptomics,Multiomics

Dataset Information

43

Systems toxicology assessment of CHTP1.2 [Liver Data]


ABSTRACT: Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxicology arm of a 90-day rat inhalation study (OECD test guideline 413) to assess the effects of CHTP1.2 aerosol compared with cigarette smoke (CS). Rats were exposed to filtered air (sham), to CHTP1.2 aerosol (at 15, 23 and 50 µg nicotine / L), or to the 3R4F reference cigarette smoke (at 23 µg nicotine / L).

OTHER RELATED OMICS DATASETS IN: PXD008424PXD008423PXD008422

INSTRUMENT(S): Affymetrix GeneChip Scanner 3000 7G

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Kogel Ulrike   Titz Bjorn   Vincenzo Belcastro   Blaine Phillips  

PROVIDER: E-MTAB-6317 | ArrayExpress | 2018-04-09

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MTAB-6317.idf.txt Idf
E-MTAB-6317.processed.1.zip Processed
E-MTAB-6317.raw.1.zip Raw
E-MTAB-6317.raw.2.zip Raw
E-MTAB-6317.sdrf.txt Txt
Items per page:
1 - 5 of 5
altmetric image

Publications

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.

Titz Bjoern B   Kogel Ulrike U   Martin Florian F   Schlage Walter K WK   Xiang Yang Y   Nury Catherine C   Dijon Sophie S   Baumer Karine K   Peric Dariusz D   Bornand David D   Dulize Remi R   Phillips Blaine B   Leroy Patrice P   Vuillaume Gregory G   Lebrun Stefan S   Elamin Ashraf A   Guedj Emmanuel E   Trivedi Keyur K   Ivanov Nikolai V NV   Vanscheeuwijck Patrick P   Peitsch Manuel C MC   Hoeng Julia J  

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180313


Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. Here, we report the results from the systems toxicology arm of a 90-day rat inhalation study (OECD test guideline 413) to assess the effects of CHTP1.2 aerosol compared with cigarette smoke (CS). Transcriptomics, proteomics, and lipidomics analyses com  ...[more]

Similar Datasets

| E-MTAB-6319 | BioStudies
| E-MTAB-6317 | BioStudies
| E-MTAB-6320 | BioStudies
2018-03-19 | PXD008423 | Pride
2018-03-19 | PXD008424 | Pride
2018-04-09 | E-MTAB-6320 | ArrayExpress
2018-04-09 | E-MTAB-6319 | ArrayExpress
2018-03-19 | PXD008422 | Pride
| E-MTAB-6610 | BioStudies
| E-MTAB-6608 | BioStudies