Genomics

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Identification of genome wide Hoxa9 binding sites in primary murine and human AML cells


ABSTRACT: Relative overexpression of HOXA9 is a key feature of aggressive AML (acute myeloid leukemia). Here we determined genome wide binding sites of Hoxa9 in primary murine cells transformed by Hoxa9 and in a human AML cell line. In addition global H3K4 monomethylation and H3K27acetylation levels were determined in cells transformed by an inducible Hoxa9-ER construct in Hoxa9-active conditions and 72h after Hoxa9 was inactivated.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Musculus  

SUBMITTER: Robert K Slany   

PROVIDER: E-MTAB-7108 | ArrayExpress | 2019-04-13

SECONDARY ACCESSION(S): ERP110292

REPOSITORIES: ArrayExpress, ENA

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