Transcriptomics

Dataset Information

298

Identification of IFNg-regulated, IRF1-dependent genes in Shigella flexneri-infected mouse embryonic fibroblasts (MEFs)


ABSTRACT: This experiment was designed to identify IFNg-regulated, IRF1-dependent genes during infection with the intracellular pathogen Shigella flexneri. WT and Irf1-/- MEFs were stimulated for 18 hours with IFNg or left unstimulated; all of the cells were subsequently infected for 6 hours with S. flexneri prior to harvest of total RNA.

ORGANISM(S): Mus musculus  

DISEASE(S): Shigella Flexneri Infection

SUBMITTER: Stephanie P Jehl  

PROVIDER: E-MTAB-713 | ArrayExpress | 2011-11-01

REPOSITORIES: ArrayExpress

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Publications

IFNγ inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I.

Jehl Stephanie P SP   Nogueira Catarina V CV   Zhang Xuqing X   Starnbach Michael N MN  

PLoS pathogens 20120809 8


The activation of host cells by interferon gamma (IFNγ) is essential for inhibiting the intracellular replication of most microbial pathogens. Although significant advances have been made in identifying IFNγ-dependent host factors that suppress intracellular bacteria, little is known about how IFNγ enables cells to recognize, or restrict, the growth of pathogens that replicate in the host cytoplasm. The replication of the cytosolic bacterial pathogen Shigella flexneri is significantly inhibited  ...[more]

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