Genomics

Dataset Information

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16S rDNA sequencing of BALB/c and C57BL/7 mouse gut microbiomes


ABSTRACT: Age-dependent changes of the gut-associated microbiome have been linked to increased frailty and systemic inflammation. This study found that age-associated changes of the gut microbiome of BALB/c and C57BL/6 mice could be reverted by co-housing of aged (22 months old) and adult (3 months old) mice for 30-40 days or faecal microbiota transplantation (FMT) from adult into aged mice. This was demonstrated using high-throughput sequencing of the V3-V4 hypervariable region of bacterial 16S rRNA gene isolated from faecal pellets collected from 3-4 months old adult and 22-23 months old aged mice before and after co-housing or FMT.

INSTRUMENT(S): Illumina MiSeq

ORGANISM(S): Mus musculus  

SUBMITTER: Marisa Stebegg   Michelle A Linterman  

PROVIDER: E-MTAB-7750 | ArrayExpress | 2019-05-08

SECONDARY ACCESSION(S): ERP114231

REPOSITORIES: ArrayExpress, ENA

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