Dataset Information


Transcriptional profiling by array in rat of age-dependent gene expression in sensorimotor cortex following spinal cord injury

ABSTRACT: In this study, we investigated the extent and nature of the difference between the dynamic cortical gene expression profiles of aged (22-month-old) and young (2-month-old) rats following thoracic corticospinal tract (CST) transection and whether the anti-scarring-treatment (AST)-induced regeneration program can be activated in aged animals. GeneChip analysis was performed on layers V/VI of the rat sensorimotor cortex at 1, 7 and 35 days post operation (dpo), which represented the acute, subacute and chronic stages of SCI, respectively. Anti-scarring treatment (AST) includes local injections of an iron chelator and cAMP immediately after SCI. For our purpose we used the Affymetrix GeneChip Rat Gene 1.0 ST Array (A-AFFY-160) which contains approximately 27,000 genes.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Hans Werner Mueller   Anne Jaerve  

PROVIDER: E-MTAB-794 | ArrayExpress | 2012-01-15


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Age-dependent modulation of cortical transcriptomes in spinal cord injury and repair.

Jaerve Anne A   Kruse Fabian F   Malik Katharina K   Hartung Hans-Peter HP   Müller Hans Werner HW  

PloS one 20121207 12

Both injury and aging of the central nervous system reportedly produce profound changes in gene expression. Therefore, aging may interfere with the success of therapeutic interventions which were tailored for young patients. Using genome-scale transcriptional profiling, we identified distinct age-dependent expression profiles in rat sensorimotor cortex during acute, subacute and chronic phases of spinal cord injury (SCI). Aging affects the cortical transcriptomes triggered by transection of the  ...[more]

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