Transcriptomics

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Expression profiling of Eµ-Myc-driven lymphomas using a reversible switchable p53 allele modeling early and late stage p53 inactivation.


ABSTRACT: For the most frequently inactivated tumor suppressor p53, genetic mouse models have demonstrated regression of p53-null tumors upon p53 reactivation. While this was shown in tumor models driven by p53 loss as the initiating lesion, many tumors initially develop in the presence of wild-type p53, acquire aberrations in the p53 pathway to bypass p53-mediated tumor suppression, and inactivate p53 itself only at later stages during metastatic progression or therapy. To explore the efficacy of p53 reactivation in this scenario, we used a reversibly switchable p53 (p53ERTAM) mouse allele to generate Eµ-Myc-driven lymphomas in the presence of active p53 and, after full lymphoma establishment, switched off p53 to model late-stage p53 inactivation.

INSTRUMENT(S): Illumina HiSeq 1500

ORGANISM(S): Mus musculus  

SUBMITTER: Jean Schneikert   Andrea Nist   Sabrina Elmshäuser   Marco Mernberger   Samet Mutlu   Boris Klimovich   Oleg Timofeev   Thorsten Stiewe  

PROVIDER: E-MTAB-8015 | ArrayExpress | 2019-10-18

SECONDARY ACCESSION(S): ERP115639

REPOSITORIES: ArrayExpress, ENA

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