Transcriptomics

Dataset Information

0

RNA-seq of primary human CD4+ T cells treated with the LXR agonist GW3965, with and without TCR stimulation


ABSTRACT: We used RNA-sequencing to determine the transcriptional response to liver X receptor (LXR) activation in primary human CD4+ T cells, both at rest and under activation conditions. CD4+ T cells were isolated from 3 healthy donors and treated with the synthetic LXR agonist GW3965 (GW) for 24 hours. Gene expression was compared to control samples (CTRL) treated with the LXR antagonist GSK1440233. To activate the T cell antigen receptor (TCR), cells were pre-treated with CTRL/GW alone for 6 hours then transferred to plates containing anti-CD3 and anti-CD28 for a further 18 hours.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens  

SUBMITTER: Inés Pineda-Torra   Kirsty E Waddington  

PROVIDER: E-MTAB-9141 | ArrayExpress | 2021-04-30

SECONDARY ACCESSION(S): ERP122047

REPOSITORIES: ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-MTAB-9141.idf.txt Idf
E-MTAB-9141.idf.txt_original Idf
E-MTAB-9141.sdrf.txt Txt
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