Transcriptomics

Dataset Information

34

Transcription profiling of listeria infected human Caco-2 cells


ABSTRACT: This experiment set contains all of the arrays described in Baldwin et al., Genome Biology, 2002. All experiments are time courses, with the exception of multiple measurements for the zero time point in the parallel time course for the purpose of zero transformation. The parallel four hour time course was performed on a single day and three independent measurements were taken prior to infection. The eight hour time courses were each performed on different days, with single time zero measurements. Each array represents a measurement of human mRNA from cultured intestinal epithelial cells (red channel), relative to the control reference pool of mRNA (green channel), at different time points during the course of an infection by Listeria monocytogenes, or the mutants actA (defective in actin-based motility) and prfA (defective in virulence factor gene expression).

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter  David Baldwin     

PROVIDER: E-SMDB-1527 | ArrayExpress| 2012-03-27

REPOSITORIES: ArrayExpress

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Publications

A gene-expression program reflecting the innate immune response of cultured intestinal epithelial cells to infection by Listeria monocytogenes.

Baldwin David N DN   Vanchinathan Veena V   Brown Patrick O PO   Theriot Julie A JA  

Genome biology 20021223 1


Listeria monocytogenes is a Gram-positive, facultative, intracellular bacterial pathogen found in soil, which occasionally causes serious food-borne disease in humans. The outcome of an infection is dependent on the state of the infected individual's immune system, neutrophils being key players in clearing the microorganism from the body. The first line of host defense, however, is the intestinal epithelium.We have examined the transcriptional response of cultured human intestinal epithelial cel  ...[more]

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