Transcriptomics

Dataset Information

3

Transcription profiling of human polarized T84 cells response to H. pylori infection, time series


ABSTRACT: All arrays use the same reference, which is cDNA generated from RNA harvested from uninfected polarized T84 monolayers. Infections were done on two seperate days. Numbers following the name of each array designate the time point post H. pylori infection. Data for time course one is named such that only this timepoint is listed, while data for time course two (wildtype and mock) is named such that the time point is followed by the designation "-2".

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter   Douglas Scott Merrell  

PROVIDER: E-SMDB-2732 | ArrayExpress | 2005-11-07

REPOSITORIES: ArrayExpress

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Publications

Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers.

El-Etr Sahar H SH   Mueller Anne A   Tompkins Lucy S LS   Falkow Stanley S   Merrell D Scott DS  

The Journal of infectious diseases 20040909 8


To extend our knowledge of host-cell targets of Helicobacter pylori, we characterized the interaction between H. pylori and human T84 epithelial cell polarized monolayers. Transcriptional analysis by use of human microarrays and a panel of isogenic H. pylori mutants revealed distinct responses to infection. Of the 670 genes whose expression changed, most (92%) required the cag pathogenicity island (PAI). Although altered expression of many genes was dependent on CagA (80% of the PAI-dependent ge  ...[more]

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