Transcriptomics

Dataset Information

35

Transcription profiling of acute myeloid leukemia FLT3 wild type and mutants in childhood AML samples from the Pediatric Oncology Group Study 9421


ABSTRACT: This data set was used to study FLT3 wild type and mutants in childhood AML samples from the Pediatric Oncology Group Study 9421. The data set was analyzed and published in the Journal Blood in 2002 by Lacayo NJ et al.

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter  Norman Lacayo     

PROVIDER: E-SMDB-2850 | ArrayExpress | 2014-05-02

REPOSITORIES: ArrayExpress

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Publications


Fms-like tyrosine kinase 3 (FLT3) mutations are associated with unfavorable outcomes in children with acute myeloid leukemia (AML). We used DNA microarrays to identify gene expression profiles related to FLT3 status and outcome in childhood AML. Among 81 diagnostic specimens, 36 had FLT3 mutations (FLT3-MUs), 24 with internal tandem duplications (ITDs) and 12 with activating loop mutations (ALMs). In addition, 8 of 19 specimens from patients with relapses had FLT3-MUs. Predictive analysis of mic  ...[more]

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