Transcriptomics

Dataset Information

32

Transcription profiling of human enosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) samples


ABSTRACT: Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations. Chromosomal translocations involving chromosome 1p13 have been reported in both TGCT and PVNS. We confirm that translocations involving 1p13 are present in a majority of cases of TGCT and PVNS and show that CSF1 is the gene at the chromosome 1p13 breakpoint. In some cases of both TGCT and PVNS, CSF1 is fused to COL6A3 (2q35). The CSF1 translocations result in overexpression of CSF1. In cases of TGCT and PVNS carrying this translocation, it is present in a minority of the intratumoral cells, leading to CSF1 expression only in these cells, whereas the majority of cells express CSF1R but not CSF1, suggesting a tumor-landscaping effect with aberrant CSF1 expression in the neoplastic cells, leading to the abnormal accumulation of nonneoplastic cells that form a tumorous mass.

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter  Matt Van De Rijn     

PROVIDER: E-SMDB-3598 | ArrayExpress| 2012-03-27

REPOSITORIES: ArrayExpress

altmetric image

Publications

A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells.

West Robert B RB   Rubin Brian P BP   Miller Melinda A MA   Subramanian Subbaya S   Kaygusuz Gulsah G   Montgomery Kelli K   Zhu Shirley S   Marinelli Robert J RJ   De Luca Alessandro A   Downs-Kelly Erinn E   Goldblum John R JR   Corless Christopher L CL   Brown Patrick O PO   Gilks C Blake CB   Nielsen Torsten O TO   Huntsman David D   van de Rijn Matt M  

Proceedings of the National Academy of Sciences of the United States of America 20060106 3


Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations. Chromosomal translocations involving chromosome 1p13 have been reported in both TGCT and PVNS. We confirm that translocations involving 1p13 are present in a majority of cases of TGCT and PVNS and show that CSF1 is the gene at the chromosome 1p13 breakpoint. In some cases of both TGCT and PVNS, CSF1 is  ...[more]

Similar Datasets

2011-10-18 | E-GEOD-4166 | ArrayExpress
2014-05-03 | E-GEOD-12157 | ArrayExpress
2008-09-30 | GSE12157 | GEO
2014-05-04 | E-GEOD-14231 | ArrayExpress
2010-03-03 | GSE14231 | GEO
2014-08-14 | E-GEOD-59257 | ArrayExpress
2015-04-27 | E-GEOD-68019 | ArrayExpress
| GSE54394 | GEO
| GSE74104 | GEO
2006-06-06 | GSE3698 | GEO