Dataset Information


Transcriptional profiling of in vivo immune responses to mycobacteria using the tuberculin skin test

ABSTRACT: Transcriptional profiling of biopsies from tuberculin skin test sites was performed to investigate the interaction of complex cellular and molecular networks at the interface between innate and adaptive immunity which coordinate anti-mycobacterial responses in vivo.

ORGANISM(S): Homo sapiens  

SUBMITTER: Gillian Tomlinson  

PROVIDER: E-TABM-1157 | ArrayExpress | 2012-05-13


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Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test.

Tomlinson Gillian S GS   Cashmore Tamaryn J TJ   Elkington Paul T G PT   Yates John J   Lehloenya Rannakoe J RJ   Tsang Jhen J   Brown Michael M   Miller Robert F RF   Dheda Keertan K   Katz David R DR   Chain Benjamin M BM   Noursadeghi Mahdad M  

European journal of immunology 20110830 11

The tuberculin skin test (TST) is a model of integrated innate and adaptive human immune responses to Mycobacterium tuberculosis, but the component processes that are involved in this model have not previously been defined in vivo. We used transcriptional profiling to study these responses within the TST at molecular and system levels. Skin biopsies from TST injection sites were examined in subjects classified as TST(+) or TST(-) by clinical and histological criteria. Genome-wide expression ar  ...[more]

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