Transcriptomics

Dataset Information

56

Transcriptional profiling by array of primary rhabdomyosarcoma samples with different PAX3/FOXO1 fusion gene status


ABSTRACT:

ORGANISM(S): Homo sapiens  

DISEASE(S): Rhabdomyosarcoma

SUBMITTER: Daniel Williamson   

PROVIDER: E-TABM-1202 | ArrayExpress | 2012-05-09

REPOSITORIES: ArrayExpress

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Publications

PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification.

Missiaglia Edoardo E   Williamson Dan D   Chisholm Julia J   Wirapati Pratyaksha P   Pierron Gaëlle G   Petel Fabien F   Concordet Jean-Paul JP   Thway Khin K   Oberlin Odile O   Pritchard-Jones Kathy K   Delattre Olivier O   Delorenzi Mauro M   Shipley Janet J  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120326 14


To improve the risk stratification of patients with rhabdomyosarcoma (RMS) through the use of clinical and molecular biologic data.Two independent data sets of gene-expression profiling for 124 and 101 patients with RMS were used to derive prognostic gene signatures by using a meta-analysis. These and a previously published metagene signature were evaluated by using cross validation analyses. A combined clinical and molecular risk-stratification scheme that incorporated the PAX3/FOXO1 fusion gen  ...[more]

Publication: 1/2

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