Transcriptomics

Dataset Information

3

Transcription profiling of human amniotic fluid after `amnion treatment with surfactant protein-A


ABSTRACT: We investigated a potential role for SP-A in human pregnancy and parturition by examining SP-A expression patterns in amniotic fluid and the amnion

ORGANISM(S): Homo sapiens  

SUBMITTER: Adi L. Tarca  

PROVIDER: E-TABM-741 | ArrayExpress | 2010-04-12

REPOSITORIES: ArrayExpress

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Publications

Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancy.

Lee Deug-Chan DC   Romero Roberto R   Kim Chong Jai CJ   Chaiworapongsa Tinnakorn T   Tarca Adi L AL   Lee JoonHo J   Suh Yeon-Lim YL   Mazaki-Tovi Shali S   Vaisbuch Edi E   Mittal Pooja P   Draghici Sorin S   Erez Offer O   Kusanovic Juan Pedro JP   Hassan Sonia S SS   Kim Jung-Sun JS  

Journal of immunology (Baltimore, Md. : 1950) 20100503 11


The mechanism of mouse parturition is thought to involve myometrial infiltration by amniotic fluid (AF) macrophages, activated by surfactant protein-A (SP-A). In humans, the concentration of AF SP-A decreases during labor, and no fetal macrophages are found in the myometrium after labor. Therefore, it appears that the mechanisms of labor in mice and humans are different. We investigated a potential role for SP-A in human pregnancy and parturition by examining SP-A expression patterns in AF and a  ...[more]

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