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Nagashima2002 - Simulating blood coagulation inhibitory effects


ABSTRACT: Mathematical model of blood coagulation and the effects of inhibitors of Xa, Va:Xa and IIa.

SUBMITTER: Matthew Roberts  

PROVIDER: MODEL1807230003 | BioModels | 2018-07-23

REPOSITORIES: BioModels

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Publications

Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation.

Nagashima Hajime H  

The Journal of biological chemistry 20021022 52


The present study began with mathematical modeling of how inhibitors of both factor Xa (fXa) and thrombin affect extrinsic pathway-triggered blood coagulation. Numerical simulation demonstrated a stronger inhibition of thrombin generation by a thrombin inhibitor than a fXa inhibitor, but both prolonged clot time to a similar extent when they were given an equal dissociation constant (30 nm) for interaction with their respective target enzymes. These differences were then tested by comparison wit  ...[more]

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