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Linke2017 - Synchronization of Cyclins' expression by the Fkh2 transcription factor in the budding yeast cell cycle


ABSTRACT: Modeling of the expression of cyclin B2 and B3 in the budding yeast cell cycle

SUBMITTER: Matthieu MAIRE   

PROVIDER: MODEL1809050002 | BioModels Database | 2018-09-06

REPOSITORIES: BioModels

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A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle.

Linke Christian C   Chasapi Anastasia A   González-Novo Alberto A   Al Sawad Istabrak I   Tognetti Silvia S   Klipp Edda E   Loog Mart M   Krobitsch Sylvia S   Posas Francesc F   Xenarios Ioannis I   Barberis Matteo M  

NPJ systems biology and applications 20170306


Precise timing of cell division is achieved by coupling waves of cyclin-dependent kinase (Cdk) activity with a transcriptional oscillator throughout cell cycle progression. Although details of transcription of cyclin genes are known, it is unclear which is the transcriptional cascade that modulates their expression in a timely fashion. Here, we demonstrate that a Clb/Cdk1-mediated regulation of the Fkh2 transcription factor synchronizes the temporal mitotic CLB expression in budding yeast. A sim  ...[more]

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