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Genome-wide analysis of DNA methylation in bronchial washings.

ABSTRACT: The objective of this study was to discover DNA methylation biomarkers for detecting non-small lung cancer (NSCLC) in bronchial washings and understanding the association between DNA methylation and smoking cessation.DNA methylation was analyzed in bronchial washing samples from 70 NSCLCs and 53 hospital-based controls using Illumina HumanMethylation450K BeadChip. Methylation levels in these bronchial washings were compared to those in 897 primary lung tissues of The Cancer Genome Atlas (TCGA) data.Twenty-four CpGs (p?

SUBMITTER: Um SW 

PROVIDER: S-EPMC5960087 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Genome-wide analysis of DNA methylation in bronchial washings.

Um Sang-Won SW   Kim Yujin Y   Lee Bo Bin BB   Kim Dongho D   Lee Kyung-Jong KJ   Kim Hong Kwan HK   Han Joungho J   Kim Hojoong H   Shim Young Mog YM   Kim Duk-Hwan DH  

Clinical epigenetics 20180518

<h4>Background</h4>The objective of this study was to discover DNA methylation biomarkers for detecting non-small lung cancer (NSCLC) in bronchial washings and understanding the association between DNA methylation and smoking cessation.<h4>Methods</h4>DNA methylation was analyzed in bronchial washing samples from 70 NSCLCs and 53 hospital-based controls using Illumina HumanMethylation450K BeadChip. Methylation levels in these bronchial washings were compared to those in 897 primary lung tissues  ...[more]