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MSI2 is required for maintaining activated myelodysplastic syndrome stem cells


ABSTRACT: Analysis of musashi2 contribution towards maintaing myelodysplastic phenotype in stem cells. We find that musashi2 plays an integral role in maintaining the myelodysplastic phenotype Control, NUP98-HOXD13; NHD13, NHD13/MSI2 bone marrow was transplated allowed to engraft into lethally irradiated congenic CD45.1 animals. Mice were then fed doxycycline to induce MSI2 overexpression. Mice were induced for 3 months and then CD45.2 Lineage lo Sca1+ and Kit+ cells were sorted and then assessed for gene expression.

SUBMITTER: Alexendar Perez 

PROVIDER: E-GEOD-76840 | BioStudies | 2016-02-16

SECONDARY ACCESSION(S): SRP068420

REPOSITORIES: biostudies

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