Unknown

Dataset Information

0

The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor.


ABSTRACT: Several herpesviruses contain open reading frames (ORFs) that encode potential homologs of eucaryotic genes. Equine herpesvirus 2 (EHV-2) is a gammaherpesvirus related to other lymphotropic herpesviruses such as herpesvirus saimiri and Epstein-Barr virus. The E1 ORF of EHV-2, a G protein-coupled receptor homolog, shows 31 to 47% amino acid identity with known CC chemokine receptors. To investigate whether E1 may encode a functional receptor, we cloned the E1 ORF and expressed it in stably transfected cell lines. We report here the identification of the CC chemokine eotaxin as a functional ligand for the EHV-2 E1 receptor. Chemokines are likely to play a role in the regulation of immune functions in equine hosts during EHV-2 infection and, via interaction with E1, may affect viral replication and/or escape from immune responses.

SUBMITTER: Camarda G 

PROVIDER: S-EPMC113033 | BioStudies | 1999-01-01

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC3835803 | BioStudies
2015-01-01 | S-EPMC4574707 | BioStudies
2019-01-01 | S-EPMC7155215 | BioStudies
1000-01-01 | S-EPMC240765 | BioStudies
2016-01-01 | S-EPMC5035975 | BioStudies
2012-01-01 | S-EPMC3503125 | BioStudies
2020-01-01 | S-EPMC7551999 | BioStudies
2016-01-01 | S-EPMC5381393 | BioStudies
2014-01-01 | S-EPMC4197165 | BioStudies
2018-01-01 | S-EPMC6042439 | BioStudies