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Hyperinsulinaemia increases insulin action in vivo in white adipose tissue but not in muscles.


ABSTRACT: The effect of 4 days of stable hyperglycaemia and resulting hyperinsulinaemia on insulin-induced glucose utilization by individual rat tissues was studied in vivo. The treatment produced a net increase in the glucose utilization index under both basal and insulin-stimulated (euglycaemic/hyperinsulinaemic clamp) conditions in white adipose tissue. On the contrary, glucose utilization was unchanged in aerobic muscles but was decreased in glycolytic skeletal muscles during the clamp.

SUBMITTER: Takao F 

PROVIDER: S-EPMC1149686 | BioStudies | 1990-01-01

SECONDARY ACCESSION(S): 10.1042/bj2720255

REPOSITORIES: biostudies

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