Unknown

Dataset Information

0

Antibody responses to Four Corners hantavirus infections in the deer mouse (Peromyscus maniculatus): identification of an immunodominant region of the viral nucleocapsid protein.


ABSTRACT: Antibody responses to Four Corners hantavirus (FCV) infections in the deer mouse (Peromyscus maniculatus) were characterized by using FCV nucleocapsid protein (N), glycoprotein 1 (G1), and glycoprotein 2 (G2) recombinant polypeptides in Western immunoblot assays. Strong immunoglobulin G reactivities to FCV N were observed among FCV-infected wild P. maniculatus mice (n = 34) and in laboratory-infected P. maniculatus mice (n = 11). No immunoglobulin G antibody reactivities to FCV G1 or G2 linear determinants were detected. The strongest N responses were mapped to an amino-proximal segment between amino acids 17 and 59 (QLVTARQKLKDAERAVELDPDDVNKSTLQSRRAAVSALETKLG). FCV N antibodies cross-reacted with recombinant N proteins encoded by Puumala, Seoul, and Hantaan viruses.

SUBMITTER: Yamada T 

PROVIDER: S-EPMC188812 | BioStudies | 1995-01-01T00:00:00Z

SECONDARY ACCESSION(S): L25783

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC236790 | BioStudies
2020-03-12 | GSE146846 | GEO
| PRJNA777211 | ENA
| PRJNA271314 | ENA
1000-01-01 | S-EPMC236491 | BioStudies
| PRJNA317926 | ENA
| PRJNA449224 | ENA
| PRJNA186524 | ENA
2013-01-01 | S-EPMC3829927 | BioStudies
| PRJNA217920 | ENA