Dataset Information


The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism.

ABSTRACT: Adipose tissue development and function play a central role in the pathogenesis and pathophysiology of metabolic syndromes. Here, we show that chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) plays a pivotal role in adipogenesis and energy homeostasis. COUP-TFII is expressed in the early stages of white adipocyte development. COUP-TFII heterozygous mice (COUP-TFII(+/-)) have much less white adipose tissue (WAT) than wild-type mice (COUP-TFII(+/+)). COUP-TFII(+/-) mice display a decreased expression of key regulators for WAT development. Knockdown COUP-TFII in 3T3-L1 cells resulted in an increased expression of Wnt10b, while chromatin immunoprecipitation analysis revealed that Wnt10b is a direct target of COUP-TFII. Moreover, COUP-TFII(+/-) mice have increased mitochondrial biogenesis in WAT, and COUP-TFII(+/-) mice have improved glucose homeostasis and increased energy expenditure. Thus, COUP-TFII regulates adipogenesis by regulating the key molecules in adipocyte development and can serve as a target for regulating energy metabolism.


PROVIDER: S-EPMC2630393 | BioStudies | 2009-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC2268152 | BioStudies
2016-01-01 | S-EPMC5345851 | BioStudies
2013-01-01 | S-EPMC3600439 | BioStudies
2019-01-01 | S-EPMC6925929 | BioStudies
2013-01-01 | S-EPMC3581189 | BioStudies
2018-01-01 | S-EPMC6287973 | BioStudies
2020-01-01 | S-EPMC7211025 | BioStudies
2012-01-01 | S-EPMC3335871 | BioStudies
1000-01-01 | S-EPMC4380653 | BioStudies
2007-01-01 | S-EPMC1779797 | BioStudies