Unknown

Dataset Information

0

Randomised aspirin assignment and risk of adult-onset asthma in the Women's Health Study.


ABSTRACT: Randomised data in men show a small but significant reduction in the risk of adult-onset asthma among those given aspirin. The results from an observational study in women suggest that frequent use of aspirin decreases the risk of adult-onset asthma, but randomised data in women are lacking. A study was undertaken to test the effect of 100 mg aspirin or placebo on alternate days on the risk of adult-onset asthma in the Women's Health Study.A randomised, double-blind, placebo-controlled clinical trial of aspirin and vitamin E was performed in apparently healthy women with no indication or contraindication to aspirin therapy and no history of asthma at study entry. Female health professionals self-reported an asthma diagnosis on yearly questionnaires.Among 37 270 women with no reported history of asthma prior to randomisation and during 10 years of follow-up, there were 872 new cases diagnosed with asthma in the aspirin group and 963 in the placebo group (hazard ratio 0.90; 95% CI 0.82 to 0.99; p = 0.027). This apparent 10% lower relative risk of incident adult-onset asthma among those assigned to aspirin was significantly modified by body mass index, with no effect in women with a body mass index of >/=30 kg/m2. The effect of aspirin on adult-onset asthma was not significantly modified by age, smoking status, exercise levels, postmenopausal hormone use or randomised vitamin E assignment.In this large randomised clinical trial of apparently healthy adult women, administration of 100 mg aspirin on alternate days reduced the relative risk of a newly reported diagnosis of asthma.

SUBMITTER: Kurth T 

PROVIDER: S-EPMC2631398 | BioStudies | 2008-01-01

REPOSITORIES: biostudies

Similar Datasets

2015-01-01 | S-EPMC4536552 | BioStudies
2009-01-01 | S-EPMC2787838 | BioStudies
2013-01-01 | S-EPMC3713531 | BioStudies
2011-01-01 | S-EPMC3062677 | BioStudies
2014-01-01 | S-EPMC3927716 | BioStudies
2014-01-01 | S-EPMC4181666 | BioStudies
1000-01-01 | S-EPMC3939660 | BioStudies
1000-01-01 | S-EPMC2774388 | BioStudies
2005-01-01 | S-EPMC555958 | BioStudies
2016-01-01 | S-EPMC4853506 | BioStudies