Unknown

Dataset Information

0

Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.


ABSTRACT: NMDA-type glutamate receptors (NMDARs) are major contributors to long-term potentiation (LTP), a form of synaptic plasticity implicated in the process of learning and memory. These receptors consist of calcium-permeating NR1 and multiple regulatory NR2 subunits. A majority of studies show that both NR2A and NR2B-containing NMDARs can contribute to LTP, but their unique contributions to this form of synaptic plasticity remain poorly understood.In this study, we show that NR2A and NR2B-containing receptors promote LTP differently in the CA1 hippocampus of 1-month old mice, with the NR2A receptors functioning through Ras-GRF2 and its downstream effector, Erk Map kinase, and NR2B receptors functioning independently of these signaling molecules.This study demonstrates that NR2A-, but not NR2B, containing NMDA receptors induce LTP in pyramidal neurons of the CA1 hippocampus from 1 month old mice through Ras-GRF2 and Erk. This difference add new significance to the observation that the relative levels of these NMDAR subtypes is regulated in neurons, such that NR2A-containing receptors become more prominent late in postnatal development, after sensory experience and synaptic activity.

SUBMITTER: Jin SX 

PROVIDER: S-EPMC2908693 | BioStudies | 2010-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5465207 | BioStudies
2004-01-01 | S-EPMC6729941 | BioStudies
2011-01-01 | S-EPMC3087383 | BioStudies
2006-01-01 | S-EPMC1693737 | BioStudies
2009-01-01 | S-EPMC2759522 | BioStudies
| S-EPMC2795512 | BioStudies
2009-01-01 | S-EPMC2652390 | BioStudies
2017-01-01 | S-EPMC5764086 | BioStudies
2018-01-01 | S-EPMC6261414 | BioStudies
2008-01-01 | S-EPMC2637039 | BioStudies