Unknown

Dataset Information

0

C-Jun promotes whereas JunB inhibits epidermal neoplasia.


ABSTRACT: Deregulation of the activator protein 1 (AP1) family gene regulators has been implicated in a wide range of diseases, including cancer. In this study we report that c-Jun was activated in human squamous cell carcinoma (SCC) and coexpression of c-Jun with oncogenic Ras was sufficient to transform primary human epidermal cells into malignancy in a regenerated human skin grafting model. In contrast, JunB was not induced in a majority of human SCC cells. Moreover, exogenous expression of JunB inhibited tumorigenesis driven by Ras or spontaneous human SCC cells. Conversely, the dominant-negative JunB mutant (DNJunB) promoted tumorigenesis, which is in contrast to the tumor-suppressor function of the corresponding c-Jun mutant. At the cellular level, JunB induced epidermal cell senescence and slowed cell growth in a cell-autonomous manner. Consistently, coexpression of JunB and Ras induced premature epidermal differentiation concomitant with upregulation of p16 and filaggrin and downregulation of cyclin D1 and cyclin-dependent kinase 4 (CDK4). These findings indicate that JunB and c-Jun differentially regulate cell growth and differentiation and induce opposite effects on epidermal neoplasia.JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article, please go to http://www.nature.com/jid/journalclub.

PROVIDER: S-EPMC3108157 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC2855785 | BioStudies
| S-EPMC2239246 | BioStudies
| S-EPMC538777 | BioStudies
| S-SCDT-EMM-2019-10697 | BioStudies
| S-EPMC6835205 | BioStudies
| S-EPMC2684448 | BioStudies
| S-EPMC3105464 | BioStudies
| E-GEOD-6559 | BioStudies
| S-EPMC3107906 | BioStudies
| S-EPMC3088632 | BioStudies