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Lipin-1? isoform is a novel lipid droplet-associated protein highly expressed in the brain.

ABSTRACT: Lipin-1 proteins are phosphatidic acid phosphatases (PAPs) catalyzing the conversion from phosphatidic acid (PA) to diacylglycerol (DG). Two alternative splicing isoforms, lipin-1? and -1?, are localized at different subcellular compartments. A third splicing isoform, lipin-1? was recently cloned and its subcellular localization is unknown. Here, we demonstrate that lipin-1? is localized to lipid droplets (LDs), an association mediated by a hydrophobic, lipin-1?-specific domain. Additional expression of lipin-1? altered LD morphology without affecting the triacylglycerol (TG) level. In human tissues, lipin-1? is the main lipin-1 isoform expressed in normal human brain, suggesting a specialized role in regulating brain lipid metabolism.


PROVIDER: S-EPMC3117272 | BioStudies | 2011-01-01

REPOSITORIES: biostudies

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