Dataset Information


High regularity of Z-DNA revealed by ultra high-resolution crystal structure at 0.55 A.

ABSTRACT: The crystal structure of a Z-DNA hexamer duplex d(CGCGCG)(2) determined at ultra high resolution of 0.55 Å and refined without restraints, displays a high degree of regularity and rigidity in its stereochemistry, in contrast to the more flexible B-DNA duplexes. The estimations of standard uncertainties of all individually refined parameters, obtained by full-matrix least-squares optimization, are comparable with values that are typical for small-molecule crystallography. The Z-DNA model generated with ultra high-resolution diffraction data can be used to revise the stereochemical restraints applied in lower resolution refinements. Detailed comparisons of the stereochemical library values with the present accurate Z-DNA parameters, shows in general a good agreement, but also reveals significant discrepancies in the description of guanine-sugar valence angles and in the geometry of the phosphate groups.

PROVIDER: S-EPMC3152349 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC8182800 | BioStudies
| S-EPMC5041494 | BioStudies
| S-EPMC4014119 | BioStudies
| S-EPMC6954431 | BioStudies
1993-01-01 | S-EPMC46701 | BioStudies
| S-EPMC4169406 | BioStudies
| S-EPMC7709202 | BioStudies
| S-EPMC5553890 | BioStudies
| S-EPMC3069751 | BioStudies
| S-EPMC14609 | BioStudies