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Stereoselective synthesis of morpholines via copper-promoted oxyamination of alkenes.

ABSTRACT: A new copper(II) 2-ethylhexanoate-promoted addition of an alcohol and an amine across an alkene (oxyamination) is reported. The alcohol addition is intramolecular, while coupling with the amine occurs intermolecularly. Several 2-aminomethyl morpholines were synthesized in good to excellent yields and diastereoselectivities.

SUBMITTER: Sequeira FC

PROVIDER: S-EPMC3465956 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

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