Unknown

Dataset Information

0

Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes.


ABSTRACT: To ascertain the genetic basis of pediatric Burkitt lymphoma (pBL), we performed clinical-grade next-generation sequencing of 182 cancer-related genes on 29 formalin-fixed, paraffin embedded primary pBL samples. Ninety percent of cases had at least one mutation or genetic alteration, most commonly involving MYC and TP53. EBV(-) cases were more likely than EBV(+) cases to have multiple mutations (P < .0001). Alterations in tumor-related genes not previously described in BL were identified. Truncating mutations in ARID1A, a member of the SWI/SNF nucleosome remodeling complex, were seen in 17% of cases. MCL1 pathway alterations were found in 22% of cases and confirmed in an expanded panel. Other clinically relevant genomic alterations were found in 20% of cases. Our data suggest the roles of MCL1 and ARID1A in BL pathogenesis and demonstrate that comprehensive genomic profiling may identify additional treatment options in refractory disease.

SUBMITTER: Giulino-Roth L 

PROVIDER: S-EPMC3537311 | BioStudies | 2012-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5746073 | BioStudies
2016-01-01 | S-EPMC4807994 | BioStudies
2016-01-01 | S-EPMC5633933 | BioStudies
2014-01-01 | S-EPMC4571983 | BioStudies
2015-01-01 | S-EPMC4462103 | BioStudies
2019-01-01 | S-EPMC6871305 | BioStudies
2018-01-01 | S-EPMC6024959 | BioStudies
2019-01-01 | S-EPMC6428665 | BioStudies
2018-01-01 | S-EPMC5980720 | BioStudies
2012-01-01 | S-EPMC3459931 | BioStudies